Johns Hopkins University, 2004 - $12,000

This E-Team developed a new device designed for the early detection of acute renal failure (ARF). The device uses laser technology and Raman spectroscopy to provide data on metabolite excretion rates in near real-time (high levels of metabolite excretion are indicative of ARF). The device enables the detection of ARF in hospitalized patients up to 48 hours earlier than current detection methods. The detection of other biomarkers using this device is also possible, making the device useful in aiding with a number of clinical diagnoses.

ARF is seen in 5% of all hospitalized patients, and 4-15% of all patients who undergo cardiovascular surgery. It accounts for 30,000 deaths per year. Current detection methods are not effective in providing early detection of the disease, which is essential to effective treatment. By providing early detection capabilities, this device can give healthcare providers a jump start on effectively treating ARF.